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22 Even worse, those bare GOx-mediated mineralized cores (GMCs) with no targeting system lacked the capability to specifically aggregate within tumor cells, which made the unsealed delivery systems potential risks to normal tissues

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Given the fairly short half-life of unbound IGF-1 in serum (i.e., 510 min), binding to an IGF binding protein (IGFBP-3 is the most prevalent) in serum or in ECM increases IGF-1 half-life to around 25 min (Allard and Duan, 2019), leading to the production of phosphatidylinositol 3,4,5-trisphosphate (PIP3) (O'Neill et al., 2015)

LY, XC, YC,YL, LY, YX, CM, and YZ collected the literature, wrote the manuscript, and prepared figures

Indication: It is primarily used to support animal metabolism, promote growth, and enhance performance